Epidemiological Appraisal- Effect of rosiglitazone on the frequency of diabetes

Medicine and Health
Epidemiological Appraisal Assignment-1 main article plus 3 key article preceding it and 3 key articles posted since (we are only given the original though)

This is a Medical School Epidemilogy Assignment.
Task begins with one paper that is flawed (despite being published in the Lancet)and we are meant to pull it apart with a focus on the appropriateness of research methods used in the study, data validity and its relevance to the objectives of the study stats used in the analysis and the interpretation therein.

The paper is Gerstein HC, Yusuf S, Bosch J, Pogue J, Sheridan P, Dinccag N, et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet (London, England). 2006;368(9541):1096-105.

Critically appraise the study, outlining the study type and methodology used (10 marks)
How do the researchers address potential limitations, confounders and bias-identify techniques used/not used to control those biases (5)
Ethical considerations (5)
(Up to 400 words for these 20 marks)

Summarise the findings and limitations of three important epidemiological studies that preceded the chosen articles. Comment on applicability, originality and importance of the literature (I am guessing you just choose three that they refer to lots as justification for doing this study) 5 marks per study-15 Marks total up to 300 words

Explain and justify why you consider these three studies to be the most important (10 marks, 100 words)

*the drug has been found to have severe side-effects including increased risk of heart attack. That probably needs to be a big focus here.

Provide 3-5 related studies, reports and guidelines that have been published since the publication of the original article (Just list or provide the references and one sentence on each as to why they are so important)

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